Rac inhibition reverses the phenotype of fibrotic fibroblasts.
BACKGROUND:Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy.Fibroblasts from lesional areas of scleroderma Heart Bracelet patients possess elevated abilities to contract matrix and produce alpha-smooth muscle actin (alpha-SMA), type I collagen and CCN2 (connecti